Research & Scholarship
Research Experience
Synthetic organic chemistry
Asymmetric catalysis
C-H bond activation
Natural product synthesis
Medicinal chemistry
PATENTS AND PUBLICATIONS
Ren, L.; Ahrendt, K.A.; Grina, J.; Laird, E.R.; Buckmelter, A.J.; Hansen, J.D.; Newhouse, B.; Moreno, D.; Wenglowsky, S.; Dinkel, V.; Gloor, S.L.; Hastings, G.; Rana, S.; Rasor, K.; Risom, T.; Sturgis, H.L.; Voegtli, W.C.; Mathieu, S. The Discovery of Potent and Selective Pyridopyrimidin-7-one Based Inhibitors of B-RafV600E Kinase. Bioorg. Med. Chem. Lett. 2012, 22, 3387-3391.
Wenglowsky, S.; Moreno, D.; Rudolph, J.; Ran, Y.; Ahrendt, K.A.; Arrigo, A.; Colson, B.; Gloor, S.L.; Hastings, G. Pyrazolopyridine Inhibitors of B-RafV600E. Part 3: An Increase in Aqueous Solubility via the Disruption of Crystal Packing. Bioorg. Med. Chem. Lett. 2012, 22, 912-915.
Wenglowsky, S.; Ahrendt, K.A.; Buckmelter, A.J.; Feng, B.; Gloor, S.L.; Gradl, S.; Grina, J.; Hansen, J.D.; Laird, E.R.; Lunghofer, P.; Mathieu, S.; Moreno, D.; Newhouse, B.; Ren, L.; Risom, T.; Rudolph, J.; Seo, J.;Sturgis, H.L.; Voegtli, W.C.; Wen, Z. Pyrazolopyridine Inhibitors of B-RafV600E. Part 2: Structure- Activity Relationships. Bioorg. Med. Chem. Lett. 2011, 21, 5533-5537.
Wenglowsky, S.; Ren, L.; Ahrendt, K.A.; Laird, E.R.; Aliagas, I.; Alicke, B.; Buckmelter, A.J.; Choo, E. F.;Dinkel, V.; Feng, B.; Gloor, S.L.; Gould, S. E.; Gross, S.; Gunzner-Toste, J.; Hansen, J.D.; Hatzivassiliou,G.; Liu, B.; Malesky, K.; Mathieu, S.; Newhouse, B.; Raddatz, N.J.; Ran, Y.; Rana, S.; Randolph, N.; Risom,T.; Rudolph, J.; Savage, S.; Selby, L.T.; Shrag, M.; Song, K.; Sturgis, H.L.; Voegtli, W.C.; Wen, Z.; Willis,B.S.; Woessner, R.D.; Wu, W.-I.; Young, W.B.; Grina, J. Pyrazolopyridine Inhibitors of B-RafV600E. :Part 1:The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors. ACS Med. Chem. Lett. 2011,2, 342-347.
Ahrendt, K. A.; Buckmelter, A. J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Newhouse, B.; Ren, L.; Wenglowsky, S. M.; Feng, B.; Malesky, K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B.; Moreno, D.A. N-(6-Aminopyridin-3-yl)-3-(Sulfonamide)Benzamide Derivatives as B-Raf Inhibitors for the Treatment of Cancer and Their Preparation. PCT Int. Appl. (2009) WO 2009111280.
Ahrendt, K. A.; Buckmelter, A. J..; De Meese, J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Lunghofer, P.; Moreno, D.; Newhouse, B.; Ren, L.; Seo, J.; Tian, H.; Wenglowsky, S. M.; Feng, B.; Gunzner, J.; Malesky,K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B. N-Pyrazolo[3,4-]pyridinyl Benzamide Derivatives as Raf Inhibitors and Their Preparation, Pharmaceutical Compositions and Use in the Treatment of Diseases. PCT Int. Appl. (2009) WO 2009111279.
Kateri Ann Ahrendt, Ahrendt, K. A.; Buckmelter, A. J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Moreno, D.; Newhouse, B.; Ren, L.;Wenglowsky, S. M.; Feng, B.; Gunzner, J.; Malesky, K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B.N-Pyrrolo[2,3-]pyridinyl Benzamide Derivatives as Raf Inhibitors and Their Preparation, PharmaceuticalCompositions and Use in the Treatment of Disease. PCT Int. Appl. (2009) WO 2009111278.
Ahrendt, K. A.; Buckmelter, A. J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Newhouse, B.; Ren, L.;Wenglowsky, S. M.; Feng, B.; Malesky, K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B.; Moreno, D.A. Imidazo[4,5-]pyridine Derivatives as Raf Inhibitors and Their Preparation and use in the Treatment of Diseases. PCT Int. Appl. (2009) WO 2009111277.
Ahrendt, K. A.; Delisle, R. K.; Hans, J.; Lyssikatos, J. P.; Robinson, J. E.; Wallace, E. M.; Zhao, Q. Preparation of Difluorophenylcarbonylphenyldihydrothiadiazole Derivatives for Use as Mitotic Kinesin Inhibitors. PCT Int. Appl. (2008) WO 2008042928.
Thalji, R. K.; Ahrendt, K. A.; Bergman, R. G.; Ellman, J. A. Annulation of Aromatic Imines via Directed CHBond Activation. J. Org. Chem. 2005, 70, 6775.
Ahrendt, K. A; Williams, R. M. A Concise Asymmetric Synthesis of the ADE Fragment of Nakadomarin A.Org. Lett. 2004, 6, 4539.
Ahrendt, K. A.; Bergman, R. G.; Ellman, J. E. Synthesis of a Tricyclic Mescaline Analogue by Catalytic CHBond Activation. Org. Lett. 2003, 5, 1301.
Ahrendt, K. A.; Olsen, J. A.; Wakao, M.; Trias, J.; Ellman, J. A. Identification of Potent and Broad Spectrum Antibiotics from SAR Studies of a Synthetic Vancomycin Analogue. Bioorg. Med. Chem. Lett. 2003, 13, 1683.
Thalji, R. K.; Ahrendt, K. A.; Bergman, R. G.; Ellman, J. A. Annulation of Aromatic Imines via Directed CH Activation with Wilkinson's Catalyst. J. Am. Chem. Soc. 2001, 123, 9692.
MacMillan, D. W. C.; Ahrendt, K. A. Chemical Synthesis Using Nonmetallic Organic Catalyst Compositions. PCT Int. Appl. (2001) WO 2001053241.
MacMillan, D. W. C.; Ahrendt, K. A. Preparation of Imidazolidinone Acid Salts as Reaction Catalysts. PCT Int. Appl. (2001) WO 2001053269.
Ahrendt, K. A.; Borths, C. J.; MacMillan, D. W. C. New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels-Alder Reaction. J. Am. Chem. Soc. 2000, 122, 4243.
Fischer, P. J.; Ahrendt, K. A.; Young, V. G., Jr.; Ellis, J. E. Trityltitanium Complexes. X-ray Structural Characterization of [Ti(CO)4{5-C(4-C6H4R)3}]- (R = H, OCH3). Organometallics 1998, 17, 13.
Professional Memberships
Reviewer for European Journal of Medicinal Chemistry, 2012
Session Chair at Gordon Research Conference in Medicinal Chemistry, Late Breaking Topics Session 2007
American Chemical Society National, Organic and Medicinal Chemistry Divisions, 1997-present